abstract：:Microvascular alterations associated with reversal of hypertension by exposure to simulated high altitude were investigated in the gracilis muscle of the spontaneously hypertensive rat (SHR). Male, 4-week-old SHR were either placed in a hypobaric chamber (SHR-HA) at 430 mmHg or maintained at ambient barometric pressur...

journal_title：Journal of hypertension

authors： Prewitt RL,Cardoso SS,Wood WB

更新日期：1986-12-01 00:00:00

abstract：:The mechanisms involved in the diuretic action of the recently discovered group of atrial natriuretic peptides (ANP) are not entirely clear. To determine whether the diuresis and the changes in blood pressure produced by alpha-human ANP (alpha-hANP) involved a concomitant modification of circulating arginine-vasopress...

journal_title：Journal of hypertension

authors： Gnädinger MP,Weidmann P,Rascher W,Lang RE,Hellmüller B,Uehlinger DE

更新日期：1986-10-01 00:00:00

abstract：:The contribution of deoxycorticosterone acetate (DOCA) and salt to arterial pressure and hypertension-related arterial wall changes was assessed in Wistar rats. One group of two-kidney DOCA-treated animals was given a high salt diet and another group a low salt diet. After 16 weeks of treatment, the animals on low sal...

journal_title：Journal of hypertension

authors： Cox RH

更新日期：1986-10-01 00:00:00

abstract：:6-Hydroxydopamine (6-OHDA) was injected on alternate days from birth to 3 weeks of age into spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) control rats. The effects of this neonatal treatment on cardiovascular structure and mesenteric resistance vessel calcium sensitivity was studied in young (6 ...

journal_title：Journal of hypertension

authors： Nyborg NC,Korsgaard N,Mulvany MJ

更新日期：1986-08-01 00:00:00

abstract：:The concentrations of neuropeptide Y immunoreactivity (NPY-ir) were measured in the cortex and cervical, thoracic and lumbar spinal cord of 8-, 18- and 31-week-old normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). This peptide was measured using a highly sensitive and specific radio-immun...

journal_title：Journal of hypertension

authors： Maccarrone C,Jarrott B

更新日期：1986-08-01 00:00:00

abstract：:To investigate the effects of changes in sodium balance on blood pressure and leucocyte sodium transport, normotensive first-degree relatives of hypertensive patients and control subjects were randomized to receive low- and high-salt diets for 2 weeks, separated by a wash-out period of 2 weeks. High-salt intake failed...

journal_title：Journal of hypertension

authors： Heagerty AM,Alton SM,el-Ashry A,Bing RF,Thurston H,Swales JD

更新日期：1986-06-01 00:00:00

abstract：:The present study was designed to investigate in rats the influence of converting enzyme inhibition with captopril on blood pressure, plasma urea, plasma renin concentration (PRC), plasma aldosterone and plasma vasopressin, and to define the interrelationships between PRC and these variables during equal degrees of ei...

journal_title：Journal of hypertension

authors： Gardes J,Gonzalez MF,Corvol P,Ménard J

更新日期：1986-04-01 00:00:00

abstract：:An index of peripheral vascular resistance, derived from directly measured arterial pressure, has been developed and tested in an animal model. Assuming a mono-exponential character for diastole, the time constant for direct arterial pressure decay in the central aorta was obtained with high-fidelity recording techniq...

journal_title：Journal of hypertension

authors： Walsh JT,Mehta SK,Topham WS,Goldberg AD

更新日期：1985-12-01 00:00:00

abstract：:The effect on blood pressure (BP) of acute and chronic suppression of angiotensin (ANG) II was studied in the two-kidney, one clip hypertensive rat. Conscious, chronically catheterized rats were given a bolus injection of captopril (2.5 mg/kg) followed by a chronic infusion of either dextrose or captopril (1 mg/kg per...

journal_title：Journal of hypertension

authors： Wallace EC,Balmforth AJ,Morton JJ

更新日期：1985-12-01 00:00:00

abstract：:Recently, there has been an explosion of knowledge on vasopressin, including its neuro-anatomy, biochemistry and physiology. Recent work demonstrates extensive extra-hypothalamic vasopressinergic projections from the SON and PVN. Of particular importance are projections to the cardiovascular medullary centres. Convers...

journal_title：Journal of hypertension

authors： Johnston CI

更新日期：1985-12-01 00:00:00

abstract：:The function of the renin-angiotensin system (RAS) is influenced by changes in sodium balance and angiotensin II (ANG II) levels. In previous studies it has been difficult to assess the physiological effects on blood pressure homeostasis of different rates of ANG II infusion and of different levels of sodium in the di...

journal_title：Journal of hypertension

authors： Olsen ME,Meydrech EF

更新日期：1985-10-01 00:00:00

abstract：:Noradrenergic activity was measured in the brainstem, hypothalamus and thoracic spinal cord of male and female spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats at 6 and 28-36 weeks of age. Two techniques were used, measurement of a major noradrenaline (NA) metabolite, free 3,4-dihydroxyphenylethyleneglycol...

journal_title：Journal of hypertension

authors： Howes LG,Summers RJ,Rowe PR,Louis WJ

更新日期：1985-06-01 00:00:00

abstract：:The binding of 125I-angiotensin II to human blood cells was investigated. Blood was drawn from healthy volunteers and platelets prepared with minimal contamination of red cells and white blood cells (less than 0.1%). Using thin layer chromatography, degradation of 125I-angiotensin II by platelets could be demonstrated...

journal_title：Journal of hypertension

authors： Mann JF,Sis J,Ritz E

更新日期：1985-04-01 00:00:00

abstract：:We have examined the mechanisms mediating the release of renin elicited in man by reduction of renal perfusion pressure. Fifteen patients with essential hypertension and six normotensive subjects were investigated during diagnostic renal arteriography. Renal neural receptors were inhibited by propranolol (10 mg i.v.) ...

journal_title：Journal of hypertension

authors： Guazzi MD,Barbier P,Loaldi A,Montorsi P,Polese A,Tosi E,Fiorentini C

更新日期：1985-02-01 00:00:00

abstract：:The purpose of this study was to examine pressor responsiveness in a rabbit model with adrenal perturbation. Adrenals in rabbits were stabbed with a needle, and the rabbits were given water (adrenal-water group) or 0.9% NaCl (adrenal-salt) to drink; additional rabbits were sham-operated and given water (sham-water gro...

journal_title：Journal of hypertension

authors： Siripaisarnpipat S,Johnson JA,Fowler WL Jr,Zeigler DW,Payne CG

更新日期：1985-02-01 00:00:00

abstract：:Normotensives with hypertensive parents have been reported to exhibit enhanced cardiovascular reactions to mental stress. We have examined the question of why this result was not confirmed in all studies. In addition we have investigated whether appropriate tests can be performed under clinical rather than laboratory ...

journal_title：Journal of hypertension

authors： Neus H,Gödderz W,Otten H,Rüddel H,von Eiff AW

更新日期：1985-02-01 00:00:00

abstract：:To assess the role of renal prostaglandin E in the hypotensive mechanism of MK-421, we evaluated the effects of chronic infusion of MK-421 (6 mg/kg/day i.p.) on systolic blood pressure and urinary prostaglandin E excretion in conscious rats in states of sodium repletion or depletion and also during chronic infusion of...

journal_title：Journal of hypertension

authors： Yasujima M,Abe K,Tanno M,Kasai Y,Sato K,Tajima J,Kudo K,Tsunoda K,Yoshinaga K

更新日期：1984-12-01 00:00:00

abstract：:Systolic blood pressure was measured on a total of 1855 occasions in 1307 children aged four and five years, and compared with values obtained since birth in the same children. There was a rapid rise in blood pressure in the first month of life. The mean blood pressure then only rose from 93 mmHg at six months to 98 m...

journal_title：Journal of hypertension

authors： de Swiet M,Fayers PM,Shinebourne EA

更新日期：1984-10-01 00:00:00

abstract：:We have demonstrated high concentrations of inactive renin in mouse amniotic fluid compared with mouse plasma and other organs. Its molecular weight was similar to that of prorenin from the mouse submaxillary gland (42 000 daltons). The activated renin had a Km value of 1.48 greater than M which is identical to that o...

journal_title：Journal of hypertension

authors： Jacobsen J,Poulsen K

更新日期：1984-10-01 00:00:00

abstract：:We have studied the norepinephrine (NE) uptake processes directly in synaptosomes isolated from the hypothalamus of both Dahl salt-sensitive (DS) and Dahl salt-resistant (DR) rats. Both DS and DR rats were divided into two dietary groups, one high salt diet group and one low salt diet group. NE uptake was highly sodiu...

journal_title：Journal of hypertension

authors： Rho JH,Hough K

更新日期：1984-10-01 00:00:00

abstract：:Carvedilol (BM 14190) is a new antihypertensive compound which combines beta-adrenoceptor blocking and precapillary vasodilating properties but is devoid of intrinsic sympathomimetic activity. The acute and long-term effects on blood pressure and regional haemodynamics (forearm plethysmography) were studied with carve...

journal_title：Journal of hypertension

authors： Eggertsen R,Sivertsson R,Andrén L,Hansson L

更新日期：1984-10-01 00:00:00

abstract：:The hormonal and hypotensive effects of a single oral 10 mg dose of enalapril (MK-421), were assessed by a double-blind randomized trial in 12 subjects with essential hypertension, during a 100 and 40 mmol/day sodium intake. Peak serum MK-421 appeared 1 h following oral dosage. The bioactive conversion product of MK-4...

journal_title：Journal of hypertension

authors： Jackson B,Cubela R,Johnston CI

更新日期：1984-08-01 00:00:00

abstract：:Blood pressure, plethysmographically determined muscle blood flow in the calf at rest and during maximal dilatation, plasma renin activity, angiotensin II and plasma and urinary aldosterone were determined in normotensive men with a positive family history of hypertension (n = 17) and in an age- and weight-matched con...

journal_title：Journal of hypertension

authors： Gudmundsson O,Andersson OK,Aurell M,Wikstrand JM,Berglund GL

更新日期：1984-06-01 00:00:00

abstract：:Vascular Na-K pump activity (ouabain-sensitive 86Rb uptake) and cardiac Na,K-ATPase activity are decreased in rats with one-kidney, one clip and reduced renal mass-saline hypertension. In the present study we measured left ventricular, microsomal Na,K-ATPase activity in rats with two steroid forms of hypertension; one...

journal_title：Journal of hypertension

authors： Clough DL,Pamnani MB,Haddy FJ

更新日期：1984-04-01 00:00:00

abstract：:The associations of obesity and alcohol consumption with blood pressure and the prevalence of hypertension were studied in 5550 male and female subjects aged 25 to 64 years, surveyed in the National Heart Foundation of Australia 1980 Risk Factor Prevalence Study. Body mass index was significantly and independently ass...

journal_title：Journal of hypertension

authors： MacMahon SW,Blacket RB,Macdonald GJ,Hall W

更新日期：1984-02-01 00:00:00

abstract：:Pinacidil is a new vasodilating compound claimed to increase renal perfusion and function. A preliminary study showed that pinacidil did not sustain renal perfusion through a period of increasing renal vascular resistance in pig-to-rabbit renal xenotransplantation. Accordingly, the effect of pinacidil on renal functio...

journal_title：Journal of hypertension

authors： Dieperink H,Kemp E,Jørgensen KA,Starklint H

更新日期：1983-12-01 00:00:00

abstract：:Systemic and regional haemodynamic effects of renal denervation were evaluated in adult (six-month-old) male spontaneously hypertensive rats (SHR) using the Fick procedure and electromagnetic flowmetry technique. Renal denervation (bilateral, 10% phenol in ethanol), performed five to eight days before the experiment, ...

journal_title：Journal of hypertension

authors： Lee JY,Walsh GM

更新日期：1983-12-01 00:00:00

abstract：:Measurements of exchangeable sodium, arterial pressure and plasma concentrations of active renin, angiotensin II, aldosterone, sodium and potassium were made in 35 hypertensive patients with renal artery stenosis, 30 having unilateral renal arterial lesions. Plasma urea was below 7 mmol/l in 24 of the patients with un...

journal_title：Journal of hypertension

authors： McAreavey D,Brown JJ,Cumming AM,Davies DL,Fraser R,Lever AF,Mackay A,Morton JJ,Robertson JI

更新日期：1983-10-01 00:00:00

abstract：:Hypertensive disease is known to increase the risks in connection with acute changes in blood pressure due to the presence of pronounced structural as well as functional changes in the cardiovascular system. In the present study the metabolic consequences of fixed haemorrhagic hypotension [mean arterial pressure (MAP)...

journal_title：Journal of hypertension

authors： Wennberg E,Hagberg H,Haljamäe H,Johansson BB

更新日期：1983-10-01 00:00:00

abstract：:Conscious male beagle dogs were given constant intravenous infusions of noradrenaline for 14 days, four receiving 125 ng/kg/min and four 250 ng/kg/min. Before, during and after these infusions dose-response studies were done in which additional noradrenaline was infused at 500, 1000 and 2000 ng/kg/min, each rate for 1...

journal_title：Journal of hypertension

authors： Casals-Stenzel J,Tree M,Brown JJ,Fraser R,Lever AF,Millar JA,Morton JJ,Robertson JI,Reid JL,Hamilton C

更新日期：1983-06-01 00:00:00

abstract：:The activity of renal Na-K-ATPase was compared in hypertension-prone (SBH) and hypertension-resistant (SBN) Sabra rats on regular sodium intake and 2-3 weeks after a high sodium diet. ATPase activity was determined in single nephron segments by a micromethod. The activity profile was found to be similar in the two sub...

journal_title：Journal of hypertension

authors： Doucet A,Mekler J,el Mernissi G,Ben-Ishay D

更新日期：1983-06-01 00:00:00

abstract：:The fall in blood pressure that is commonly observed when groups of hypertensive individuals are followed without treatment is usually ascribed to two sources: regression towards the mean and increasing familiarity of the subject with the assessment process. Any effect of the latter process could bias the results of c...

journal_title：Journal of hypertension

authors： Haynes RB,Logan AG,Flanagan PT,Milne BJ

更新日期：1983-06-01 00:00:00